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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1958 1
1963 1
1964 1
1965 1
1966 4
1967 6
1968 5
1969 8
1970 18
1971 20
1972 17
1973 13
1974 18
1975 106
1976 78
1977 71
1978 67
1979 65
1980 85
1981 98
1982 114
1983 117
1984 129
1985 138
1986 135
1987 161
1988 174
1989 174
1990 197
1991 215
1992 202
1993 224
1994 241
1995 261
1996 290
1997 277
1998 310
1999 321
2000 388
2001 375
2002 361
2003 379
2004 386
2005 434
2006 476
2007 490
2008 467
2009 479
2010 477
2011 495
2012 524
2013 544
2014 538
2015 483
2016 479
2017 505
2018 534
2019 505
2020 508
2021 553
2022 552
2023 547
2024 200

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14,835 results

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Page 1
Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis.
Zahra K, Dey T, Ashish, Mishra SP, Pandey U. Zahra K, et al. Front Oncol. 2020 Mar 2;10:159. doi: 10.3389/fonc.2020.00159. eCollection 2020. Front Oncol. 2020. PMID: 32195169 Free PMC article. Review.
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is catalyzed by Pyruvate Kinase. ...The oligomers of PKM2 exist in high activi …
Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is t …
Unblocking the rate-limiting step of the municipal sludge anaerobic digestion.
Wang J, Sun Y, Zhang D, Broderick T, Strawn M, Santha H, Pallansch K, Deines A, Wang ZW. Wang J, et al. Water Environ Res. 2022 Oct;94(10):e10793. doi: 10.1002/wer.10793. Water Environ Res. 2022. PMID: 36184901 Free PMC article.
Anaerobic digestion stabilizes municipal sludge through total solids reduction and biogas production. It is generally accepted that hydrolysis accounts for the rate-limiting step of municipal sludge anaerobic digestion, impacting the overall rates of solids r …
Anaerobic digestion stabilizes municipal sludge through total solids reduction and biogas production. It is generally accepted that hydrolys …
Rate-limiting recovery processes in neurotransmission under sustained stimulation.
Ernst A, Unger N, Schütte C, Walter AM, Winkelmann S. Ernst A, et al. Math Biosci. 2023 Aug;362:109023. doi: 10.1016/j.mbs.2023.109023. Epub 2023 May 26. Math Biosci. 2023. PMID: 37245846
A sensitivity analysis on the recovery rates based on the ODE formulation reveals that neither the vesicle nor the release site recovery step can be identified as the essential rate-limiting step but that the rate-limiting feature changes …
A sensitivity analysis on the recovery rates based on the ODE formulation reveals that neither the vesicle nor the release site recovery …
Prediction of Rate-Limiting Reactions for Growth-Associated Production Using a Constraint-Based Approach.
Tokuyama K, Toya Y, Shimizu H. Tokuyama K, et al. Biotechnol J. 2019 Sep;14(9):e1800431. doi: 10.1002/biot.201800431. Epub 2019 Jul 11. Biotechnol J. 2019. PMID: 31218797
Identification of a rate-limiting step in pathways is a key challenge in metabolic engineering. ...These predictions include experimentally identified rate-limiting steps, which would contribute to metabolic engineering as a practical tool for s …
Identification of a rate-limiting step in pathways is a key challenge in metabolic engineering. ...These predictions in …
Rethinking metabolic control.
Morandini P. Morandini P. Plant Sci. 2009 Apr;176(4):441-51. doi: 10.1016/j.plantsci.2009.01.005. Epub 2009 Jan 20. Plant Sci. 2009. PMID: 26493133 Review.
The main reason is our limited understanding of metabolic plasticity and metabolic control, with the latter still largely influenced by the idea that each pathway has a rate limiting step controlling the flux. Not only is experimental evidence for such steps …
The main reason is our limited understanding of metabolic plasticity and metabolic control, with the latter still largely influenced by the …
Proposed protocol for rate-limiting step determination during anaerobic digestion of complex substrates.
Tsigkou K, Zagklis D, Parasoglou M, Zafiri C, Kornaros M. Tsigkou K, et al. Bioresour Technol. 2022 Oct;361:127660. doi: 10.1016/j.biortech.2022.127660. Epub 2022 Jul 21. Bioresour Technol. 2022. PMID: 35872279
During the rate limiting step determination, several compounds (biopolymer and monomer representatives, as well as sodium acetate) were used, combined or not with the substrate, to draw the corresponding conclusions. ...All three substrates followed the aceta …
During the rate limiting step determination, several compounds (biopolymer and monomer representatives, as well as sodi …
Rate-limiting steps in cytochrome P450 catalysis.
Guengerich FP. Guengerich FP. Biol Chem. 2002 Oct;383(10):1553-64. doi: 10.1515/BC.2002.175. Biol Chem. 2002. PMID: 12452431 Review.
One of the considerations about functional characterization is which steps of the catalytic cycle are rate-limiting. Detailed analysis indicates that several different steps can be rate-limiting with individual P450 reactions. ...In the oxidations of e …
One of the considerations about functional characterization is which steps of the catalytic cycle are rate-limiting. Detailed …
Determination of the Rate-Limiting Step in Fatty Acid Transport.
Cheng V, Kimball DR, Conboy DJC. Cheng V, et al. J Phys Chem B. 2019 Aug 22;123(33):7157-7168. doi: 10.1021/acs.jpcb.9b05162. Epub 2019 Aug 12. J Phys Chem B. 2019. PMID: 31334654
The generally accepted model of free fatty acid (FA) transport through cellular membranes occurs in three steps, adsorption of the FA onto the membrane, translocation across the membrane ("flip-flop"), and subsequent desorption of the FA into the cytosol. There still exists some …
The generally accepted model of free fatty acid (FA) transport through cellular membranes occurs in three steps, adsorption of the FA onto t …
Rate-limiting steps in metabolic pathways.
Rognstad R. Rognstad R. J Biol Chem. 1979 Mar 25;254(6):1875-8. J Biol Chem. 1979. PMID: 422559 Free article.
A method is proposed to detect whether a given enzyme catalyzes a rate-limiting step in a metabolic pathway. With the use of a range of concentrations of specific inhibitors of an enzyme, the finding of a biphasic response with an initial null effect indicate …
A method is proposed to detect whether a given enzyme catalyzes a rate-limiting step in a metabolic pathway. With the u …
The Rate-limiting Step of DNA Synthesis by DNA Polymerase Occurs in the Fingers-closed Conformation.
Evans GW, Craggs T, Kapanidis AN. Evans GW, et al. J Mol Biol. 2022 Jan 30;434(2):167410. doi: 10.1016/j.jmb.2021.167410. Epub 2021 Dec 17. J Mol Biol. 2022. PMID: 34929202 Free PMC article.
Here, we advance our analysis to extensible substrates, and observe DNA polymerase (Pol) conformational changes across the entire DNA polymerisation reaction in real-time, gaining direct access to an elusive post-chemistry step rate-limiting for DNA synthesis …
Here, we advance our analysis to extensible substrates, and observe DNA polymerase (Pol) conformational changes across the entire DNA polyme …
14,835 results
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